Rated 4.9 | 25,000+ Customers

The Supplement Built for Your GLP-1 Journey

Fast-acting enzymes for immediate relief. Probiotics for lasting gut health. Built around the digestion your GLP-1 creates — not the one you used to have.

check_circle Made for GLP-1 guts — not generic digestive support

check_circle Sulfur burps & bloating fade in days — not months

check_circle Breaks food down before it ferments — where the burps start

check_circle Ends the bathroom whiplash — no more can't-go, can't-leave

check_circle Keeps you on your shot — don't lose your progress to a side effect

verified_user 60-Day Risk-Free

Made in USA

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Gastric Enzyme Complex

 4.9/5
$59.00
$59.00 $69.00
SAVE 14% Sold out
 
  • Stops sulfur burps and nausea at the source — not downstream
  • Relief within 30–60 minutes of your first dose
  • Ends the constipation/diarrhea cycle over 2–4 weeks
  • Replaces Gas-X, Pepto, ginger, and enzymes in 2 capsules
  • Zero fermentable fiber — won't aggravate your already-slowed system

Makzyme-Pro™ 2500 HUT / 400mg - Clinically standardized enzyme blend. Pre-digests stagnant proteins before fermentation.

Bromelain 90 GDU - The science behind the pineapple remedy your GLP-1 forum discovered.

Papain 2670 TU - Targets dense proteins causing sulfur gas.

Alpha-Galactosidase 300 GALU - Eliminates gas from vegetables, beans, and carbs. Unique in this category.

Tri-Probiotic Blend L. acidophilus + L. casei + L. plantarum - Restores motility. Ends the diarrhea/constipation cycle.

Take1 capsule 20–30 minutes before your two main meals. 2 capsules per day.

Works with any GLP-1 injection schedule — weekly or daily. Enzyme relief within 30–60 min. Probiotic benefit builds over 2–4 weeks.

Yes. ORYN contains zero fermentable fibers, zero stimulants, and no known drug interactions with Ozempic, Wegovy, Mounjaro, or Zepbound. Safe to take alongside any GLP-1 injection on any schedule.

We know you need relief yesterday.
Dealing with GLP-1 side effects is exhausting, which is why we don't make you wait.

  • Fast Delivery: Orders arrive in 2 to 4 business days anywhere in the US.
  • Shipped from the USA: Proudly manufactured and dispatched directly from our US-based facilities (no overseas delays).
  • Shipping Cost: FREE shipping on all Subscriptions AND 3-Month / 6-Month bundles. (A small flat rate applies only to single-bottle, one-time purchases).

60-Day Money-Back Guarantee: Not feeling relief? We'll refund every penny — no questions, no return needed.

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The shot kept working So did they.

Why thousands of GLP-1 users won't start their week without ORYN.

Susan K.
★ ★ ★ ★ ★
Susan K. 54
Verified Buyer

« I lost 42 lbs on Wegovy. The sulfur burps started in week 3, I genuinely thought I'd quit. I couldn't be around my husband, couldn't eat dinner without leaving the table. ORYN stopped them in two days. I'm still on my shot 8 months later. »

Alex J.
★ ★ ★ ★ ★
Alex J. 47
Verified Buyer

« I'm down 95 lbs in 11 months on Ozempic. The math was simple... I spent $1000/month on the injection and I was about to lose all of it to constipation by month two. ORYN was $50. It's the cheapest decision I made the entire year. »

Marsha T.
★ ★ ★ ★ ★
Marsha T. 38
Verified Buyer

« Mounjaro changed my body. The bloating almost made me give up. I stopped going out, stopped saying yes to anything that involved food. Two weeks on ORYN and I had my first restaurant dinner in months. I'm down 115 lbs and I'm actually living again. »

Vincent L.
★ ★ ★ ★ ★
Vincent L. 39
Verified Buyer

« I started ORYN the same week I started Mounjaro my doctor warned me about the gut side effects and I wasn't going to mess around. Best decision I made. No sulfur burps, no bloating in the gym, no quitting halfway. Down 94 lbs in 8 months and I refuse to run out of oryn. My wife buys the next bottle before this one's empty. »

Linda R.
★ ★ ★ ★ ★
Linda R. 51
Verified Buyer

« You know that 3am wake-up when your stomach feels like it's about to burst? That was every single night for me on Zepbound. My daughter is the one who found oryn she said « mom just try it. » I've slept through every night for the past 10 months. Down 127 lbs. Still on the shot. Thanks, kid. »

You're not weak. Your stomach was chemically stopped.

GLP-1 medications reduce gastric motility by design. It's not a side effect — it's the mechanism. And no one told you what to do about it.

0%

of GLP-1 patients quit within the first year.
Most say: "it made me sick."

0%

gastric retention at 4 hours.
Clinical gastroparesis threshold is 10%.

0%

of patients experienced GI side effects
for 2 full years — without relief.*

*Based on pooled data from the STEP 1–5 trials and the SELECT cardiovascular outcomes trial (n=17,604).

86% saw significant GI improvement in clinical trials.

Here's what that actually feels like.

 Excellent
 

I was two weeks away from stopping my shots.

"Four months on Wegovy. Losing weight, but feeling miserable every single day. My doctor said eat bland food… and that was pretty much the only advice I got. I stumbled on the pineapple trick online, then found out ORYN had the same enzyme science built into it. Two capsules before each meal. The sulfur burps eased up, the bloating calmed down, and I threw out four other products that same week."

Susan M., 54
On Wegovy · 6 months
 

The weight is coming off. My life wasn't.

"Four months on Wegovy. The weight was coming off, but every meal felt heavy.
My doctor said eat bland food. That was it. Then I saw the pineapple trick online and found ORYN uses the same enzyme science. Two capsules before m. The sulfur burps eased, the bloating felt calmer, and I stopped juggling four different products."

Linda T., 58
On Wegovy · 4 months
 

Food just sat there. Then nothing moved.

"Even small meals felt stuck for hours. Then I’d go days without being able to go. The nausea, burps and constipation were wearing me down, and I was close to quitting Ozempic. ORYN was the first thing that actually made sense. Two weeks in, things felt more predictable and I finally felt human again."

Michael D., 51
On Ozempic · 5 months

How ORYN works — and when.

  1. start

    Hour 01

    Enzyme Intervention

    Your stomach has been holding food hostage. ORYN's enzymes break it down immediately — proteins, fats, carbs — before they ferment into gas and nausea. The cleanup starts before you leave the table.

  2. recycling

    Day 03-05

    Gastric pressure reduces.

    Less gas building up. Fewer sulfur burps. Your stomach empties the way it's supposed to. You eat dinner and just... move on with your evening.

  3. compress

    Day 14

    Your Gut Bacteria Rebuild

    Three probiotic strains start recolonizing your gut. The random diarrhea and constipation cycles out. Your digestion becomes something you can predict again.

  4. check_circle

    Day 30

    You Feel Human Again

    Enzymes at every meal. Probiotics working around the clock. Fast relief and long-term repair — running together, every day. That's the biphasic effect. You stay on your medication. You stay on track.

CLINICALLY FORMULATED

Not a gut supplement. A GLP-1 companion.

check_box

Your gut changed. Your supplement should too.

GLP-1 medications slow gastric emptying by design. Most digestive supplements don't account for this, they were formulated for a gut that moves food at normal speed. ORYN is built around slowed motility: fast-acting enzymes that break food down before it ferments, not after.

Most supplements do one thing. ORYN does two: Makzyme-Pro™, Bromelain, and Papain attack food breakdown within 30 minutes. Three probiotic strains (L. acidophilus, L. casei, L. plantarum) rebuild the gut flora that months of slow digestion have disrupted. Immediate relief and long-term repair — in one capsule.

ORYN was formulated specifically for the digestive pattern GLP-1 medications create: delayed gastric emptying, reduced motility, altered gut microbiome. Not a generic enzyme blend with a new label. The formula addresses the mechanism, not just the symptoms.

Fiber supplements worsen bloating when gastric emptying is already slow — your gut can't process what it can't move. Laxatives create urgency and dependency. ORYN uses zero fiber and zero stimulant laxatives. It works with your slowed gut, not against it.

 
 

Find out why the experts trust ORYN_

 

Susan Alford , Gastroenterologist , PhD

"Most patients on GLP-1s are eating less but absorbing even less. ORYN's enzyme complex ensures every gram of protein and fat actually gets used. That matters enormously when calories are this restricted."

Dr. Sam Herraka, Gastroenterologist · GLP-1 Specialist

"Zero fermentable fibers. No drug interactions. ORYN is a clean formulation built specifically for GLP-1 users. From a pharmacology standpoint, it's exactly what this population needs."

Holly L. Adams, MD Gastroenterologist

"The combination of enzymes and probiotics in ORYN is exactly what GLP-1 patients are missing. Enzymes address the immediate fermentation problem. Probiotics rebuild what the medication disrupts over time. That's the right sequence."

Dr. Lukasz Kwapisz , MD Internal Medicine

"Your medication slows your stomach by design. ORYN works with that mechanism, not against it. For my patients who struggle with GI side effects, it's the missing piece in the protocol."

The only formula built for GLP-1 digestion.

Most supplements weren't designed for a stomach that's been chemically slowed. ORYN was.

  Others
GLP-1 specific formulation
Biphasic action — fast relief + long-term repair
Zero fermentable fibers
Works in 30 minutes
Probiotic gut repair
Safe alongside all GLP-1 medications

•

Formulated for GLP-1-induced gastroparesis

•

7 enzymes. Every macronutrient covered.

•

Immediate relief + long-term gut normalization

•

Safe alongside all GLP-1 medications

•

Formulated for GLP-1-induced gastroparesis

•

7 enzymes. Every macronutrient covered.

•

Immediate relief + long-term gut normalization

•

Safe alongside all GLP-1 medications

•

Formulated for GLP-1-induced gastroparesis

•

7 enzymes. Every macronutrient covered.

•

Immediate relief + long-term gut normalization

•

Safe alongside all GLP-1 medications

•

Formulated for GLP-1-induced gastroparesis

•

7 enzymes. Every macronutrient covered.

•

Immediate relief + long-term gut normalization

•

Safe alongside all GLP-1 medications

Your questions. Straight answers.

Customer avatar (Verified reviewer)
Customer avatar (Verified reviewer)
Customer avatar (Verified reviewer)
Formulated by our expert in-house
GLP-1 digestive specialists

We built ORYN for one specific problem.
Here's everything you need to know.

Most probiotics add fermentable bacteria into a stomach that's already moving too slowly making bloating worse before it gets better. ORYN works differently. The enzymes act first, breaking down food before it ferments. The probiotics work downstream, restoring regularity over time. That sequence matters. It's why ORYN works from day one, while most probiotics take weeks just to settle in.

The enzymes activate within 30 minutes of your first meal. Most users notice a reduction in sulfur burps and post-meal heaviness within the first 3 days. Full biphasic effect — enzymes plus probiotics working together — is typically established by week 4. Take 1 capsule 20–30 minutes before your two main meals, every day.

Yes. Digestive enzymes and Lactobacillus probiotics are generally recognized as safe and carry no known interactions with GLP-1 medications. ORYN contains zero fermentable fibers — the ingredient class most likely to cause aggravation in a slowed GI tract. As always, inform your prescribing physician of any supplement you add to your regimen.

For best results, take 1 capsule before your two largest meals of the day. If you eat lightly — which many GLP-1 users do — once daily is sufficient. Consistency matters more than frequency. Daily use is what allows the probiotic component to rebuild gut motility over time.